Stage-specific expression of microRNAs duringXenopusdevelopment

Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas.

miRNAs are small RNA molecules binding to partially complementary sites in the 3'-UTR of target transcripts and repressing their expression. miRNAs orchestrate multiple cellular functions and play critical roles in cell differentiation and cancer development. We analyzed miRNA profiles in B-cell subsets during peripheral B-cell differentiation as well as in diffuse large B-cell lymphoma (DLBCL)...

Stage-Specific Expression of Surface Antigens

Myogenic factors that regulate expression of muscle-specific microRNAs.

Since their discovery as key regulators of early animal development, microRNAs now are recognized as widespread regulators of gene expression. Despite their abundance, little is known regarding the regulation of microRNA biogenesis. We show that three highly conserved muscle-specific microRNAs, miR-1, miR-133 and miR-206, are robustly induced during the myoblast-myotube transition, both in prim...

Cell-type-specific signatures of microRNAs on target mRNA expression.

Although it is known that the human genome contains hundreds of microRNA (miRNA) genes and that each miRNA can regulate a large number of mRNA targets, the overall effect of miRNAs on mRNA tissue profiles has not been systematically elucidated. Here, we show that predicted human mRNA targets of several highly tissue-specific miRNAs are typically expressed in the same tissue as the miRNA but at ...

LYMPHOID NEOPLASIA Differentiation stage–specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas

miRNAs are small RNA molecules binding to partially complementary sites in the 3 -UTR of target transcripts and repressing their expression. miRNAs orchestrate multiple cellular functions and play critical roles in cell differentiation and cancer development. We analyzed miRNA profiles in B-cell subsets during peripheral B-cell differentiation as well as in diffuse large B-cell lymphoma (DLBCL)...